The Center for Energy Efficient Electronics Science (E3S) was established in 2010 as a consortium of world class academic institutions working together as a Science and Technology Center (STC) funded by the U. S. National Science Foundation.

Until its sunset in 2021, the Center for E3S provided a collaborative and innovative education and research environment enabling fundamental and conceptual breakthroughs in the underlying physics, chemistry, and materials science of electronic systems — breakthroughs needed to reduce energy consumption by orders of magnitude.